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褪黑素有望用于宇航员骨质疏松的预防和治疗

来源:新华网 时间:2019-07-24 15:53:08

新华社东京7月24日电(记者华义)日本一项新研究发现,褪黑素能抑制太空环境下的骨吸收。研究人员据此认为,今后有望将褪黑素用于宇航员骨质疏松的预防和治疗。

骨吸收是指在较低的应力水平下,骨组织的体积和密度逐渐下降的生理现象。通常骨吸收和骨生长同时存在,形成动态平衡,而太空失重及较高水平的电离辐射环境容易造成宇航员骨质疏松。

日本金泽大学等机构研究人员在美国《松果体研究杂志》上发表报告说,在国际空间站日本宇航员的配合下,利用金鱼鳞在太空进行了有关褪黑素作用的实验,然后将实验样本带回了地球。研究人员说,金鱼鳞和哺乳动物骨骼具有同样的激素应答机制,因此可用作骨骼研究模型。金鱼鳞的骨芽细胞,即处于骨细胞早期发育阶段的细胞能够产生褪黑素。

研究发现,在太空环境中,金鱼鳞褪黑素的合成水平下降了。对比实验发现,与不添加褪黑素的金鱼鳞相比,人为添加褪黑素后的金鱼鳞骨吸收现象得到抑制,骨吸收速度放慢。

研究小组认为,这一研究成果显示,未来有可能利用褪黑素开发药物,帮助进入太空的宇航员预防和治疗骨质疏松。

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